Dr. Santiago Gómez-Ruiz

Professor of Inorganic Chemistry, Department of Biology and Geology, Physics and Inorganic Chemistry. Rey Juan Carlos University, Spain

Santiago Gómez-Ruiz (1978, Toledo, Spain) received his B.Sc. in Chemistry from the Universidad de Castilla La Mancha (Spain) (1996-2001). Then, he joined the Rey Juan Carlos University as Assistant Professor (Profesor Ayudante de Escuela Universitaria) being the youngest teaching staff member of the School of Experimental Sciences and Technology (ESCET). In 2003, he spent three months in the laboratory of Prof. Hey-Hawkins at Leipzig University (Germany) as "Marie Curie Training Site Fellow" working on Homogeneous and Heterogeneous Catalysis, specifically in the synthesis of P-containing group 5 metallocenes. This collaboration allowed the description of the first niobocene complex with a phosphanidoalkylcyclopentadienyl ligand which was an important milestone for Nb(V) chemistry and was published later in the prestigious journal Organometallics (Organometallics 2005, 24, 2061-2064).

In December 2004, he finished his Ph.D. thesis focused on the synthesis and catalytic properties of novel metallocene complexes "Design and Applications of Novel Group 4 and 5 Metallocene Complexes" with the highest qualification ("Summa Cum Laude") and the European Diploma. He was awarded a new position in the URJC (Profesor Ayudante Doctor) in 2005. He has also worked in a project for knowledge transfer with the petroleum company Repsol.

He obtained one of the most prestigious postdoctoral research fellowship from the renowned Alexander Von Humboldt Foundation which only awards approximately 500 fellowships per year for all the disciplines and nationalities. As Alexander Von Humboldt Fellow (2006-2007) he worked in the field of P-Chemistry leading one of the research topics of the group focused on phosphorus-rich transition metal complexes. From his postdoctoral stay at Leipzig University working in Prof. Hey-Hawkins' group he published 13 articles in journals of high impact such as Chemistry - European Journal, Inorganic Chemistry or Coordination Chemistry Reviews. In parallel to his project on P-rich metal complexes, he helped in the supervision of some of the PhD students of the group and started to collaborate with different groups improving his knowledge in Coordination Chemistry and Nanomaterials and widening his knowledge and looking for an independent research position.

In December 2007 he was appointed as Associate Professor (Profesor Contratado Doctor) and back to his University (URJC) he decided to begin a new research topic based on the design and preparation of novel metallodrugs and nanostructured materials with biological applications against cancer. He has been leading the research topic of metallodrugs and nanostructured materials since 2008 and his leadership has been widely consolidated by a large number of publications in high impact journals in which he is the corresponding author of all the contributions.

In August 2009 he was awarded as Professor of Inorganic Chemistry (Profesor Titular de Universidad) at the Rey Juan Carlos University being the youngest Professor in the Area of Inorganic Chemistry at national level. Since 2010 he is also leading other different research topics focused on the synthesis of nanostructured materials with angiogenic applications and the preparation of novel advanced materials with catalytic and photocatalytic applications with important contributions in journals of high impact such as Biomaterials Science or Science of the Total Environment.

Due to his pioneering research work on the use of nanostructured materials functionalized with metallodrugs in the fight against cancer he has been invited by several journals to publish contributions (see for example: Chem. Eur. J. 2014, 20, 10811) and also as plenary or invited speaker in prestigious international conferences.

In addition, since 2012, he has been principal investigator of various research projects for knowledge transfer with the American Company Chevron Phillips Chemical. These projects are focused on the anticancer applications of zirconocene derivatives and nanostructured materials, therefore, he is close to companies and market requirements in the area of metal complexes and materials with catalytic and biological applications. He keeps a close relationship with other SMEs such as Yflow, Pharmacoidea, Empireo and Biosolutions and is involved in the application of NMBP-H2020 projects which includes some of these companies.

Starting from 2001, he has participated in 17 research projects and has been principal investigator of a competitive Exchange Research Project with University of Leipzig funded by DAAD. In addition, he is principal investigator of the project "Design of innovative functionalized nanomaterials: Exploring their multifunctional applications in catalysis and medicinal chemistry" (CTQ-2015-66164-R) funded by the Ministry of Economy and Competitiveness (Program "Retos de Investigación").

He has also supervised two PhD students and four master students. He collaborates with several groups from China, India, Germany, Austria, Romania, Serbia, Algeria, Spain, UK, Switzerland and USA.

He also has teaching experience in subjects in the first, second and third cycle of different scientific degrees with more than 1600 theoretical and practical hours. He has actively worked in 7 Teaching Innovation Projects and has published 6 teaching books as co-author and one chapter in an international book. In addition, he has presented 19 communications in teaching conferences.

1. Publications.

Dr. Gómez-Ruiz has published 123 articles in high impact international journals indexed in JCR (28 as first author and 45 as corresponding author), from which can be highlighted some articles in journals such as Angew. Chemie Int. Ed. (IF ca. 11,3), Coord. Chem. Rev. (IF ca. 11.0), Chem. - Eur. J. (IF ca. 5.5). J. Mater. Chem. (IF ca. 5.1), etc. In addition, he has written chapters in the books: "Catalysis and Material Science Applications Series, Catalysis by Metal Complexes" Vol. 36. (Springer, 2011) and "Molecules at Work. Selfassembly, Nanomaterials, Molecular Machinery" (Wiley, 2012). The ten most important papers of his career are (in reverse chronological order with Dr. Gómez-Ruiz as lead author):

1. Nanostructured Materials Functionalized with Metal Complexes: In Search of Alternatives for Administering Anticancer Metallodrugs, Coord. Chem. Rev. 2016, 312, 67. (Highly cited article in the top 1% of most cited articles in Inorganic Chemistry from its publication according to ISI Web of Knowledge metrics)

2. Design, synthesis and characterization of doped‐titanium oxide nanomaterials with environmental and angiogenic application. Science of The Total Environment 2017, 599-600C, 1263.

3. Curcumin loaded mesoporous silica: an effective drug delivery system for cancer treatment. Biomater. Sci. 2016, 4, 448

4. Photodegradation of organic pollutants in water and green hydrogen production via methanol photoreforming of doped titanium oxide nanoparticles, Sci. Total Environ. 2016, 563-564, 921.

5. Ether-substituted group 4 Metallocene complexes: cytostatic effects and applications in ethylene polymerization. Organometallics 2015, 34, 2522

6. Dual application of Pd nanoparticles supported on mesoporous silica: Supported catalysts for C−C coupling reactions and cytotoxic agents against human cancer cell lines. RSC Advances 2014, 5, 54775.

7. Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer Treatment, Angew. Chemie Int. Ed. 2014, 53, 5982.

8. Anticancer Applications of Titanocene-Functionalized Nanostructured Systems: An Insight into Cell Death Mechanisms. Chem. - Eur. J. 2014, 20, 10811.

9. Study of the cytotoxicity and particle action in human cancer cells of titanocene-functionalized materials, J. Inorg. Biochem. 2012, 106, 100.

10. A new generation of anticancer drugs. Mesoporous materials modified with titanocene complexes. Chem. - Eur. J. 2009, 15, 5588.

2. Granted patents

Cutting-edge research in metallodrugs in collaboration with Martin-Luther Halle-Wittenberg University in Germany led to patent ionic organotin derivatives due their potent cytotoxicity:

Title: Anionischen Organozinnverbindungen. Application Number: 10 2003 038 549.5

Priority country: Germany, priority date: 22/08/2009. Owner: Martin-Luther Halle-Wittenberg University.

3. Invited presentations to peer-reviewed, internationally established conferences and/or international advanced schools

Dr. Gómez-Ruiz has presented more than 75 contributions in conferences, many of them as invited oral communications and has given more than 25 lectures about his research in different universities and research centres worldwide. Plenary Lectures at: 10th International Joint Conference On Chemistry (JCC, Surakarta, Indonesia, 2015), 4th International Conference on Pharmacy and Advanced Pharmaceutical Sciences (Yogyakarta, Indonesia, 2015), 4th International Conference for Young Chemists (Penang, Malaysia, 2013) among others. Invited Lectures at: 1st Nanotek Conference (2016, Hamburg, Germany), 4th EuCheMS Chemistry Congress (Nürnberg, Germany, 2012), 1st International Conference of Young Chemists (Amman, Jordan, 2012), 8 International Conference of the Chemical Societies of the South East European Countries (Belgrade, Serbia, 2014), REACH-2015 (Shillong, India, 2015) among others. Invited Lectures at: Technische Universität Dortmund (Germany), Ludwig Maximillian Universität München (Germany), Jiangsu University (China), Nanjing University (China), Hanyang University (South Korea), Tohoku University (Japan), Indian Institute of Chemical Technology Hyderabad (India), Brooklyn College (USA), De La Salle University (Manila, Philippines), Monash University (Malaysia), University of Malaya (Malaysia) and Sebelas Maret University (Indonesia) among others.

4. Prizes, awards and academy memberships and management

Finalist of the "3rd European Young Chemist Award 2010" celebrated in the 3rd EuCheMS Chemistry Congress. Founder and Secretary of the Young Section of Spanish Royal Society of Chemistry (November 2008 to November 2011). He has been Spanish representative of the European Young Chemists' Network (EYCN) (February 2010 to October 2013) and currently is "Advisor" of EYCN.

Last update 24th May 2017

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